Pop Isaacs scored 27 points, Ryan Kalkbrenner added 17 points and 10 rebounds, and Creighton beat No. 1 Kansas 76-63 on Wednesday night in Omaha, Neb., for the Jayhawks’ first loss of the seasonIsaacs shot 6-for-9 from beyond the arc and added seven rebounds and four assists. His contested layup with 3:14 to play pushed Creighton’s lead to 73-57 as the program notched its second win over a No. 1 team in school history. (The Bluejays beat UConn 85-66 last season.)Steven Ashworth contributed 17 points, eight rebounds and six assists as the Bluejays (6-3) defeated Kansas for the first time since 1949. Kalkbrenner, Creighton’s star center, was back after missing one game due to a lower-body injury.Dajuan Harris Jr. scored 15 points for Kansas (7-1). AJ Storr and Zeke Mayo each scored 12 in the loss.No. 9 Duke 84, No. 2 Auburn 78Freshman phenom Cooper Flagg scored 16 of his game-high 22 points in the second half, helping the Blue Devils beat the visiting Tigers in Durham, N.C., in the SEC/ACC Challenge.Flagg also had 11 rebounds for the Blue Devils (6-2), who won their second straight game despite trailing by 11 in the opening minutes. Isaiah Evans added 18 points for Duke, while Tyrese Proctor chipped in 12 and Caleb Foster 11.Johni Broome had 20 points and 12 rebounds for Auburn (7-1), which allowed a season high in points. Tahaad Pettiford also scored 20 for the Tigers, followed by Chad Baker-Mazara’s 17. Miles Kelly added 14 points and three steals.No. 6 Iowa State 81, No. 5 Marquette 70Keshon Gilbert scored 24 and Joshua Jefferson added 15 to lead the Cyclones past the Golden Eagles in Ames, Iowa.Iowa State (6-1) also got 14 off the bench from Curtis Jones. Gilbert dished out a team-high seven assists while Jefferson grabbed 12 boards.Marquette (8-1) was led by 17 from freshman Royce Parham. Kam Jones added 14 along with nine assists and eight rebounds despite shooting just 6-of-21 from the field.No. 10 Alabama 94, No. 20 North Carolina 79Mark Sears scored 20 points to lead six Alabama players in double figures as the Crimson Tide recorded a runaway victory over the Tar Heels in the SEC/ACC Challenge in Chapel Hill, N.C.It was a rematch of a Sweet 16 matchup last season, which was also won by Alabama, but this one didn’t live up to the billing. Labaron Philon and Aden Holloway both had 15 points, Clifford Omoruyi and Derrion Reid had 11 apiece and Grant Nelson provided 10 for the Crimson Tide (7-2).Freshman Ian Jackson scored a season-high 23 points for North Carolina (4-4), which has lost three games in a row. RJ Davis racked up 18 points, and Seth Trimble had 12 points.No. 12 Oregon 68, Southern California 60Jackson Shelstad scored 21 of his 24 points in the second half and Keeshawn Barthelemy provided pivotal plays down the stretch as the Ducks rallied to top the Trojans in Los Angeles in the Big Ten opener for both teams.Oregon (9-0, 1-0 Big Ten) went on a 14-2 run late in the second half to flip a game it trailed most of the way. Shelstad kicked off the Ducks’ key stretch, which lasted 3:01 and extended past the final media timeout, with the first six points.USC (5-4, 0-1) took its third consecutive loss, a byproduct of the Trojans’ poor shooting. USC went 19-for-55 (34.5 percent) from the floor and just 2-for-13 (15.4 percent) from 3-point range. Oregon shot 8-for-23 (34.8 percent) from deep and 21-for-55 (38.2 percent) overall.No. 13 Florida 87, Virginia 69Walter Clayton Jr. scored 27 points as the Gators remained undefeated with a victory over the Cavaliers in the SEC/ACC Challenge in Gainesville, Fla.Alex Condon contributed 19 points and eight rebounds while Alijah Martin added 16 points for the Gators (9-0). Florida is off to its best start since the 2005-06 season, when it won its first 17 games and captured the NCAA championship.San Diego State transfer Elijah Saunders scored a career-high 19 points and Isaac McKneely added 12 points, all on treys, for Virginia (5-3).